Origin of breast cancer

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Breast cancer is the most common incident form of cancer in women including different subtypes. Cancer stem cells CSCs have been confirmed to exist in breast cancer. We identified the putative origin cells of BCSSCs through comparing gene signatures between BCSSCs and normal mammary cells from multiple perspectives: common signature, expression consistency, functional similarity and shortest path length.

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Breast cancer is not a single disease, but rather is composed of distinct subtypes associated with different clinical outcomes. Understanding this heterogeneity is key for the development of targeted cancer-preventative and -therapeutic interventions. Current models explaining inter- and intratumoral diversity are the cancer stem cell and the clonal evolution hypotheses.

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Breast cancer is the most common cancer type in women in Sweden and worldwide. It has long been known that not all breast cancers are similar: Luminal tumours consist mostly of cells that are similar to those found in the inner lining of the breast ducts luminal mammary gland cellswhereas others can have cells more similar to the outer layer of the breast epithelium basal cells. It is believed that this diversity originates from mutations in different stem cells or progenitor cells.

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November 2, Breast cancer is the most common cancer type in women in Sweden and worldwide. It has long been known that not all breast cancers are similar: Luminal tumours consist mostly of cells that are similar to those found in the inner lining of the breast ducts luminal mammary gland cellswhereas others can have cells more similar to the outer layer of the breast epithelium basal cells.

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Career Opportunities. Roberto Bonelli. The mammary gland is comprised of three main cell types; alveolar, ductal and myoepithelial cells.

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Our purpose is to develop a testable biological hypothesis to explain the known increased risk of breast cancer associated with extensive percent mammographic density PMDand to reconcile the apparent paradox that although PMD decreases with increasing age, breast cancer incidence increases. We used the Moolgavkar model of carcinogenesis as a framework to examine the known biological properties of the breast tissue components associated with PMD that includes epithelium and stroma, in relation to the development of breast cancer. In this model, normal epithelial cells undergo a mutation to become intermediate cells, which, after further mutation, become malignant cells.

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Breast cancer is cancer that develops from breast tissue. Risk factors for developing breast cancer include being female, obesitylack of physical exercise, drinking alcoholhormone replacement therapy during menopauseionizing radiationearly age at first menstruationhaving children late or not at all, older age, prior history of breast cancer, and family history. The balance of benefits versus harms of breast cancer screening is controversial.

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Identifying the cellular origins of breast cancer might lead to earlier diagnosis and more efficient management of the disease. New research led by Charlotte Kuperwasser of Tufts University School of Medicine TUSM has determined that common forms of breast cancer originate from breast cells known as luminal epithelial cells while rarer forms of breast cancer, such as metaplastic carcinomas, originate from basal epithelial cell types. The study was published online ahead of print this week in PNAS Early Edition as part of its breast cancer special feature. Clinicians and researchers classify breast cancers into subtypes based on both clinical features and molecular features, including expression of certain genes and proteins.

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Biological studies confirm that breast cancer is the result of an accumulation of a large number of individual genetic mutations that collectively alter elements of the complex internal signaling system of a cell. These aberrant genetic alterations, when assembled in a single breast cell, disrupt the control system to the extent that the cell functions autonomously in an erratic and irregular manner. Continual replication of a corrupted cell results in the formation of a colony of abnormal cells that may accumulate other aberrant mutations to eventually initiate cancer. What causes these mutations has been the topic of debate over a number of years, but because so many genetic alterations are involved, it is now conceded that one single factor could not possibly initiate all the changes.

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